半岛bd体育手机客户端 说明
一般描述
Iron regulatory proteins (IRP-1 and IRP-2) are cytoplasmic mRNA-binding proteins that control intracellular iron levels by regulating the translation of ferritin, Tfrs, and other proteins congaing iron-responsive element (IRE) located at the 5′-UTR. IRP binds to IREs with high affinity in situation of iron starvation. Binding of IRP to IRE of ferritin represses its transcription. However, when cells are iron replete, IRPs lose their capacity to bind IREs, allowing efficient translation of ferritin and reducing Tfr mRNA half-life. Although IRP1 and IRP-2 share significant protein sequence homology, they differ in tissue distribution and mode of regulation. IRP-2/IRE-BP2 (rat/human 963 aa) is relatively less abundant than IRP-1 and lacks aconitase activity. It has a unique 73-aa insertion in the N-terminus. In the presence of high iron levels, IRP-2 is rapidly targeted to proteasome-mediated degradation. Although, both IRPs bind the consensus IREs, it is also shown that IRP-2 can recognize an exclusive IRE subset.
特异性
Iron regulatory protein 2 (IRP-2). The immunogen sequence has no significant homology with IRP-1.
The immunogen sequence is 100% conserved in human, rat, and mouse IRP-2.
免疫原
Synthetic peptide near the N-terminus of human/rat/mouse IRP-2.
应用
Detect Iron Regulatory Protein 2 using this Anti-Iron Regulatory Protein 2 Antibody validated for use in ELISA & WB.
外形
Liquid in PBS with 0.1% BSA and 0.05% sodium azide.
ImmunoAffinity Purified
Format: Purified
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | purified antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
species reactivity | mouse, human, rat |
manufacturer/tradename | Chemicon? |
technique(s) | ELISA: suitable western blot: suitable |
NCBI登记号 | NM_004136.2 |
UniProt登记号 | P48200 |
运输 | dry ice |
Gene Information | human ... IREB2(3658) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 2 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich