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位置: 首页> 品牌> Sigma-Aldrich> Anti-Histone Deacetylase 7 (HDAC7) (KG-17) antibody produced in rabbit

Anti-Histone Deacetylase 7 (HDAC7) (KG-17) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
H2662
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
4731.57 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Histone Deacetylase 7 (HDAC7) (KG-17) antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Mammalian histone deacetylases (HDACs) can be divided into three classes according to sequence homology. Class I consists of the yeast transcriptional regulatory protein Rpd3-like proteins HDAC1, HDAC2, HDAC3, and HDAC8. Class II consists of the yeast Hda1-like proteins HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10. Class III consists of the yeast sirtuin 2 (Sir2)-like proteins. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm.

特异性

Anti-Histone Deacetylase 7 recognizes human, mouse, and rat HDAC7.

免疫原

Synthetic peptide corresponding to amino acids of human HDAC7, conjugated to KLH.

应用

Anti-Histone Deacetylase 7 (HDAC7) (KG-17) antibody produced in rabbit has been used in

  • indirect immunofluorescene
  • immunoblotting
  • immunoprecipitation

包装

200 μL in glass insert

生化/生理作用

Class II histone deacetylases (HDACs) have been implicated in the regulation of muscle differentiation. Interaction of HDAC4, -5, and -7 with members of the myocyte enhancer factor-2 (Mef2) family of transcription factors represses their transcriptional activity and prevents myogenesis. Shuttling of HDAC7 between the cell nucleus and the cytoplasm is controlled by a mechanism involving calmodulin independent kinase I (CaMKI) and 14-3-3 proteins. The HDAC7 enzymatic activity depends on its interaction with the class I HDAC3, and the corepressors silencing mediator of retinoic acid and thyroid hormone receptors (SMRT) and nuclear receptor co-repressor (N-COR). HDAC7 also interacts with the transcriptional repressor B-cell lymphoma 6 (BCL-6).

外形

Solution in 0.01 M phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD04040364
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~105 kDa
species reactivity human, mouse, rat
technique(s) immunoprecipitation (IP): 1.0-1.5 μg using RIPA extract of 293T cells expressing recombinant human HDAC7
indirect immunofluorescence: 1:50 using rat NRK cells
western blot: 1:1,000 using whole extracts of mouse NIH-3T3 cells
UniProt登记号 Q8WUI4
运输 dry ice
储存温度 ?20℃
Gene Information human ... HDAC7(51564)
mouse ... Hdac7(56233)
rat ... Hdac7a(84582)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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