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位置: 首页> 品牌> Sigma-Aldrich> Anti-ZIP-8 Antibody

Anti-ZIP-8 Antibody

品牌
Sigma-Aldrich
货号
ABF197
规格纯度
from rabbit, purified by affinity chromatography
价格
4681.07 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-ZIP-8 Antibody
Zinc transporter ZIP8, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, ZIP-8, Zrt- and Irt-like protein 8
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Zinc transporter ZIP8 (UniProt Q9C0K1; also known as BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6, Solute carrier family 39 member 8, ZIP-8, Zrt- and Irt-like protein 8) is encoded by the SLC39A8 (also known as BIGM103, ZIP8, PP3105) gene (Gene ID 64116) in human. Zinc transporters mediate the transport of zinc ions into intracellular compartments as well as the export of excess zinc out of cells. Disruption of zinc homeostasis is responsible for many chronic neurodegenerative diseases and acute neural injuries. Excessive and inadequate levels of bioavailable zinc are detrimental to the health of neurons. Two classes of multipass transmembrane Zn transporters are known, including 10 ZnTs and 14 ZIPs, that exhibit opposing functions in mediating zinc homeostasis. These transporters are located on plasma and vesicular membranes with tissue-specific expression pattern. ZIP8 is a negative regulator of the NF-κB signaling pathway through zinc-mediated suppression of IKK activity in monocytes, macrophages, and lung epithelia. ZIP8 expression is induced following innate immune activation and correlates with intracellular zinc sequestration. Human ZIP8 is an 8-transmembrane protein (a.a. 9-29, 133-153, 161-181, 192-212, 303-323, 366-386, 389-409, 430-450) that has both its N- and C-termini (a.a. 1-8 & 451-460) exposed extracelluarly with 4 intracellular and 3 extracellular loops in between.

特异性

Immunogen sequence is present in all three spliced isoforms of human ZIP-8 reported by UniProt (Q9C0K1).

免疫原

KLH-conjugated linear peptide corresponding to a sequence within the second extracellular loop of human ZIP-8.

应用

This Anti-ZIP-8 Antibody is validated for use in Western Blotting for the detection of ZIP-8.

质量

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2.0 ?g/mL of this antibody detected ZIP-8 in 10 ?g of human lung tissue lysate.

目标描述

~52 kDa observed. Target band size appears larger than the calculated molecular weights of 49.63/43.13/48.09 kDa (human isoform 1/2/3) due to glycosylation.

外形

Affinity Purified

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) nonhuman primates (based on 100% sequence homology)
technique(s) western blot: suitable
NCBI登记号 NP_071437
UniProt登记号 Q9C0K1
Gene Information human ... SLC39A8(64116)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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