Anti-TRPM4 Antibody

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一般描述

TRPM4, also known as Calcium-activated non-selective cation channel 1, Long transient receptor potential channel 4, Melastatin-4 or LTrpC4, and encoded by the gene TRPM4/LTRPC4, is a calcium activated non-selective ion channel for Na+, K+, Cs+ and Li+ ions. TRPM4 plays a central role in membrane depolarization in cardiomyocytes, cortical and dorsal root neurons, endocrine cells, kidney epithelial cells and even hair cells. Additionally, TRPM4 participates in T-cell activation, IL-2 production, blood vessel constriction, insulin secretion and even cell proliferation in various cell types through the up regulation of the beta catenin signaling pathway. TRPM4 is localized to the cell membrane and golgi apparatus and endoplasmic reticulum. TRPM4 is widely expressed. Defects in TRPM4 may be associated with progressive familial heart block disorder which can be a fatal though unpredictable syndrome.

免疫原

BCP-conjugated linear peptide corresponding to human TRPM4 near the N-terminal.

应用

Anti-TRPM4 Antibody detects level of TRPM4 & has been published & validated for use in TRPM4.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRPM4 in human cerebellum and human prostate tissue.

质量

Evaluated by Western Blotting in human cerebellum tissue lysate.

Western Blotting Analysis: 0.5 ?g/mL of this antibody detected TRPM4 in 10 ?g of human cerebellum tissue lysate.

目标描述

~150 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~130 kDa and ~147 kDa

外形

Affinity purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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