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位置: 首页> 品牌> Sigma-Aldrich> Anti-GADD153/DDIT3/CHOP Antibody

Anti-GADD153/DDIT3/CHOP Antibody

品牌
Sigma-Aldrich
货号
ABC955
规格纯度
from rabbit, purified by affinity chromatography
价格
5426.21 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-GADD153/DDIT3/CHOP Antibody
DNA damage-inducible transcript 3 protein, DDIT-3, C/EBP zeta, C/EBP-homologous protein, CHOP, C/EBP-homologous protein 10, CHOP-10, CCAAT/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, GADD153/DDIT3/
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

DNA damage-inducible transcript 3 protein (UniProt P35638; also known as CCAAT/enhancer-binding protein homologous protein, C/EBP-homologous protein 10, C/EBP zeta, CHOP, CHOP-10, DDIT-3, Growth arrest and DNA damage-inducible protein GADD153) is encoded by the DDIT3 (also known as CEBPZ, CHOP, CHOP10, GADD153) gene in human (Gene ID 1649). CHOP is a proapoptotic unfold protein response (UPR) gene and a well established marker for ER stress and UPR activation. The accumulation of unfolded or misfolded proteins in the ER induces the activation of three main UPR pathways, the inositol requiring enzyme-1 (IRE1) pathway, the activating transcription factor 6 (ATF6) pathway, and the protein kinase-like ER kinase (PERK) pathway. The PERK pathway involves PERK auto-phosphorylation/activation, resulting in PERK phosphorylation of eIF2α, which in turn leads to increased ATF4 transcription and ATF4-mediated CHOP upregulation.

免疫原

Epitope: Near N-terminus
KLH-conjugated linear peptide corresponding to human GADD153/DDIT3/CHOP near the N-terminus.

应用

Research Sub Category
Apoptosis - Additional
This Anti-GADD153/DDIT3/CHOP antibody is validated for use in Western Blotting for the detection of GADD153/DDIT3/CHOP.
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in Tunicamycin treated HeLa cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected GADD153/DDIT3/CHOP in 10 ?g of Tunicamycin treated HeLa cell lysate.

目标描述

~29 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
species reactivity (predicted by homology) rat (based on 100% sequence homology), monkey (based on 100% sequence homology), porcine (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s) western blot: suitable
NCBI登记号 NP_004074
UniProt登记号 P35638
运输 wet ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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