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Anti-Osteopontin antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200018
规格纯度
clone OPN46, purified from hybridoma cell culture
价格
5045.46 *本价格含增值税费
促销
服务
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  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-Osteopontin antibody, Mouse monoclonal
Anti-BNSP
Anti-OPN
Anti-Uropontin
Anti-SPP1
Anti-Early T Lymphocyte Activation Protein 1 (ETA1)
Anti-Urinary stone protein
Anti-Bone Sialoprotein 1
Anti-Secreted Phosphoprotein 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-Osteopontin (mouse IgG1 isotype) is derived from the hybridoma OPN46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human osteopontin. Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein which serves as a cytokine and as an extracellular matrix molecule. It is produced by multiple tissues in the body and is most abundant in bone.

应用

Monoclonal Anti-Osteopontin antibody produced in mouse may be used in immunoblotting.

生化/生理作用

Osteopontin (OPN) synthesized in cancer cells is essentail for growth, progression and metastasis of cancer. In tuomr cells OPN is highly expressed The structural features of OPN differ between normal and tumor cells Three osteopontin splice variant transcripts have been found to be expressed in invasive, but not in non-invasive breast tumor cell lines. Osteopontin-b lacks exon 5 and osteopontin-c lacks exon 4. The shortest splice variant, osteopontin-c may support breast tumor progression by conveying anchorage independence and inducing oxidoreductases expression. It was also suggested as a diagnostic and prognostic breast cancer marker.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 OPN46, monoclonal
形式 buffered aqueous solution
分子量 antigen ~60 kDa
species reactivity mouse, human, canine, rat, monkey
浓度 ~1.0 mg/mL
technique(s) western blot: 5-10 μg/mL using HepG2 cells extract
同位素/亚型 IgG1
UniProt登记号 P10451
运输 dry ice
储存温度 ?20℃
Gene Information human ... SPP1(6696)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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