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位置: 首页> 品牌> Sigma-Aldrich> Anti-NR4A2 (N-terminal) antibody produced in rabbit

Anti-NR4A2 (N-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
N6413
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
5531.3 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-NR4A2 (N-terminal) antibody produced in rabbit
Anti-TINUR
Anti-HZF-3
Anti-RNR1
Anti-NOT
Anti-NURR1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.

应用

Anti-NR4A2 (N-terminal) antibody has been used in

  • immunoblotting
  • immunofluorescence
  • western blotting

生化/生理作用

NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.
Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.

目标描述

NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 ~70 kDa
species reactivity human, mouse, rat
浓度 ~1.5 mg/mL
technique(s) indirect immunofluorescence: 4-8 μg/mL using 3T3 cells
western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2
UniProt登记号 P43354
运输 dry ice
储存温度 ?20℃
Gene Information human ... NR4A2(4929)
mouse ... Nr4a2(18227)
rat ... Nr4a2(54278)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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