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Anti-IGF-1 antibody produced in goat

品牌
Sigma-Aldrich
货号
SAB3600001
规格纯度
affinity isolated antibody, lyophilized powder
价格
7915.51 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-IGF-1 antibody produced in goat
Anti-Insulin-like Growth Factor-I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Insulin-like growth factor-I (IGF-I) is encoded by the gene mapped to human chromosome 12q23.2. IGF-I belongs to insulin-like growth factor (IGF) family. The encoded protein is ubiquitously expressed, but the circulating form of the protein is mainly found in liver and pancreas.

免疫原

purified,E. coli-derived recombinant human insulin-like growth factor-I.

应用

Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml. The recommended antibody concentration for immunocytochemistry is 5-15 μg/ml. The antibody is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded sections.

生化/生理作用

Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate. Anti-IGF-I recognizes human insulin-like growth factor I.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00162566
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 goat
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
形式 lyophilized powder
species reactivity human
technique(s) immunocytochemistry: 5-15 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: 0.1-0.2 μg/mL
application(s) research pathology
储存温度 ?20℃
Gene Information human ... IGF1(3479)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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