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Anti-EB1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
E3406
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
6036.26 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-EB1 antibody produced in rabbit
Anti-End-Binding-1
Anti-APC binding protein EB1
Anti-Microtuble-associated protein RP/EB family member 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Microtubule-associated protein RP/EB family member 1 is a protein encoded by the MAPRE1 gene in humans. EB1 (End-Binding-1) proteins belong to a distinct family of accessory proteins, termed “plus-end tracking proteins” or +TIPs, that bind to the plus-ends of microtubules. All EB1 family proteins have a highly conserved N-terminal region that contains a calponin homology (CH) domain and an EB1-like C-terminal motif, which is unique to EB1 family proteins.

免疫原

synthetic peptide corresponding to amino acids 252-268 located at the C-terminus of human EB1, conjugated to KLH. This sequence is identical in several species (mouse, rat, dog, bovine, and porcine EB1), highly conserved (single amino acid substitution) in chicken EB1, and has limited homology to human EB2 (35% identity) and human EB3 (53% identity).

应用

Anti-EB1 antibody produced in rabbit has been used in

  • immunofluorescence
  • western blotting
  • immunocytochemistry
  • immunoprecipitation

生化/生理作用

End-Binding-1 (EB1) associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.
The C-terminal domain of End-binding proteins (EBs) is important for its autonomous microtubule tip tracking, regulation of microtubule dynamics, chromosome segregation and recruitment of numerous partners to microtubule ends. EB1 proteins bind to microtubule ends and act with the adenomatous polyposis coli (APC) tumor suppressor to regulate the microtubule filament system. It is a potential oncogene and plays an important role during early event in colon carcinogenesis, colorectal cancer (CRC). EB1 acts as a potential biomarker and therapeutic target in CRC.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01633308
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 35 kDa
species reactivity mouse, canine, bovine, pig, human, rat
浓度 ~1.5 mg/mL
technique(s) immunoprecipitation (IP): 10-20 μg using cell lysate of the human epitheloid carcinoma HeLa cell line
indirect immunofluorescence: 1-2 μg/mL using rat fibroblast Rat1 cells
indirect immunofluorescence: suitable
western blot: 0.5-1 μg/mL using cell lysate of the rat fibroblast cell line Rat1 or Rat 2
UniProt登记号 Q15691
运输 dry ice
储存温度 ?20℃
Gene Information human ... MAPRE1(22919)
mouse ... Mapre1(13589)
rat ... Mapre1(114764)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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