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Anti-COMT antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C6870
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
5827.44 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-COMT antibody produced in rabbit
Anti-Catechol-O-methyltransferase
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Catechol-O-methyltransferase (COMT) is encoded by the gene mapped to human chromosome 22q11.21. It is widely expressed in neuronal and non-neuronal tissues. In mammals, two isoforms of COMT have been identified a cytosolic soluble form (S-COMT) and a membrane-bound form (MB-COMT), whose relative levels differ in various tissues and species.

特异性

The antibody recognizes MB-COMT and S-COMT.

应用

Anti-COMT antibody produced in rabbit has been used in enzyme linked immunoassay (ELISA).
Anti-COMT antibody produced in rabbit is suitable for immunoprecipitation at a concentration of 5-10μL using human HepG2 cell lysates and western blotting at a dilution of 1:250-1:500 using whole extracts of mouse and rat liver.

生化/生理作用

Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamine neurotransmitters including dopamine, noradrenaline, and adrenaline, their metabolites, and L-DOPA. Its major physiological role is to inactivate biologically active or toxic catechols. Variations in enzymatic activity of COMT result in the pathogenesis of different psychiatric and neurological diseases. COMT inhibitors are important therapeutic agents used in the treatment of Parkinson′s disease.
Catechol-O-methyltransferase (COMT) is referred as HEL-S-98n. The COMT Met/Met genotype individuals can acquire skill in executive function tasks (as multi-UV supervisory control to a higher level and faster than other genotype groups). The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children.

目标描述

COMT (Catechol-O-methyltransferase) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD03454916
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~24 kDa (and ~28 kDa)
species reactivity mouse, rat, human
technique(s) immunoprecipitation (IP): 5-10 μL using human HepG2 cell lysates
western blot: 1:250-1:500 using whole extracts of mouse and rat liver
UniProt登记号 P21964
运输 dry ice
储存温度 ?20℃
Gene Information human ... COMT(1312)
mouse ... Comt1(12846)
rat ... Comt(24267)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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