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Anti-Cathepsin D antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
SAB4200767
规格纯度
clone CTD-19, purified from hybridoma cell culture
价格
7637.11 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Cathepsin D antibody, Mouse monoclonal
Anti-CTSD, cleaved into the following 2 chains: Cathepsin D light chain and Cathepsin D heavy chain
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anti-Cathepsin D antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the CTD-19 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with cathepsin D purified from human liver. Cathepsin D (CatD or CTSD) is synthesized in the rough endoplasmic reticulum as pre-proprotein. After removal of signal peptide, the pro-CatD is targeted to endosomes to form an active, ~48 kDa, single-chain intermediate then to the lysosomes to form the fully active mature protease, composed of a ~30 kDa heavy chain and a ~14 kDa light chain.

免疫原

Cathepsin D Purified from human liver

应用

Anti-Cathepsin D antibody, Mouse monoclonal has been used in:

  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

生化/生理作用

CatD plays numerous physiological functions in the cells including metabolic degradation of intracellular proteins and the activation of enzymatic precursors. In the central nervous system, CatD is particularly important for the control of neuronal homeostasis, cell migration and interneuron communication. CatD-mediated proteolysis mediates the degradation of unfolded/oxidized protein aggregates in lysosome. The level of CatD synthesized by the cells is increased in response to mitogenic signals from estrogen, epidermal growth factor (EGF), fibroblast growth factor (FGF), and insulin like growth factor-I (IGF- I). The ability of tumor cells to invade the extracellular matrix has been attributed to cathepsins released by tumor cells or associated with its plasma membrane.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 300
生物来源 mouse
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 CTD-19, monoclonal
形式 buffered aqueous solution
species reactivity rabbit, human
浓度 ~1.0 mg/mL
technique(s) immunoblotting: 2-4 μg/mL using human breast cancer MCF7 cell line
immunofluorescence: 5-10 μg/mL using HeLa cells
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human liver sections
同位素/亚型 IgG2a
UniProt登记号 P07339
运输 dry ice
储存温度 ?20℃

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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