Anti-Aromatase Antibody

半岛bd体育手机客户端 说明

一般描述

Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.

特异性

Other homolgoies: Rat and Mouse (94% sequence homology).

免疫原

KLH-conjugated linear peptide corresponding to human Aromatase.

应用

Anti-Aromatase Antibody is an antibody against Aromatase for use in WB.
Western Blot Analysis: 1 ?g/mL from a representative lot detected Aromatase in 10 ?g of human testis.
Research Sub Category
Neurochemistry & Neurotrophins
Research Category
Neuroscience

质量

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 0.5 ?g/mL of this antibody detected Aromatase in 10 ?g of human placenta tissue lysate. Tween was not used in the Western Blot.

目标描述

~58 kDa observed. UniProtKB/Swiss-Prot P11511 (CP19A_HUMAN) states a molecular weight of ~58 kDa

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Human placenta tissue lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	100
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
纯化方式	affinity chromatography
species reactivity	pig, human
species reactivity (predicted by homology)	rhesus macaque (based on 100% sequence homology), porcine (based on 100% sequence homology), bovine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), canine (based on 100% sequence homology)
technique(s)	western blot: suitable
NCBI登记号	NP_000094
UniProt登记号	P11511
运输	wet ice

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable