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位置: 首页> 品牌> Sigma-Aldrich> Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit

Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
H4539
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
6366.52 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit
Anti-HD11
Anti-HDAC11
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anti-Histone Deacetylase 11 (HDAC11) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH, as immunogen. Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6. This gene is mapped to human chromosome 3p25.

免疫原

synthetic peptide corresponding to amino acids 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by three amino acids in both rat and mouse HDAC11.

应用

Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting analysis.

生化/生理作用

Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Histone Deacetylase 11 (HDAC11) modulates immune activation and tumorigenesis. It negatively controls the synthesis of interleukin-10 (IL-10) in antigen-presenting cells (APCs). It also modulates type I interferon (IFN) signalling.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD06202148
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~39 kDa
species reactivity mouse, human
浓度 ~1 mg/mL
technique(s) western blot (chemiluminescent): 0.5-1 μg/mL using extracts of mouse brain
western blot (chemiluminescent): 4-6 μg/mL using nuclear extracts of HeLa cells.
UniProt登记号 Q96DB2
运输 dry ice
储存温度 ?20℃
Gene Information human ... HDAC11(79885)
mouse ... Hdac11(232232)
rat ... Hdac11(297453)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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