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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse

Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
I2032
规格纯度
clone 33627.11, purified immunoglobulin, lyophilized powder
价格
14385.8 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse
Anti-IGFBP-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The effects of insulin-like growth factors (IGF) are modulated by a family of insulin-like growth factor binding proteins 1-6. (IGFBPs -1-6). IGFBP-1 is secreted as an endocrine factor by liver, kidneys, decidua and in human amniotic fluid, but has the ability to signal in autocrine and paracrine fashion. Post-translational modifications such as ubiquitination, glycosylation and phosphorylation alter the activity of IGFBPs. Phosphorylation of IGFBP-1 is mainly mediated by Casein kinase I and II and cAMP-dependent protein kinases. IGFBP-1 alters the bioavailability of IGF in the serum by binding and sequestration so that a regulated amount id available to act on the target cells. The functions of IGFBP-1 are most important in the physiology of female reproductive system in mammals, for growth and development of the developing fetus
Monoclonal Anti-Human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) recognizes recombinant human IGFBP-1. No cross-reactivity is seen with recombinant human IGFBP-2, IGFBP-3, and IGFBP-4.

特异性

The biological activity is measured by its ability to neutralize recombinant human IGFBP-1 in the presence of recombinant human IGF-I.

免疫原

purified recombinant human insulin-like growth factor binding protein 1, expressed inE. coli.

应用

Anti- Insulin-Like Growth Factor Binding Protein-1 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 2 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 10-40 μg/ml).

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD01322209
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 33627.11, monoclonal
形式 lyophilized powder
species reactivity human
technique(s) capture ELISA: suitable
neutralization: suitable
western blot: 1-2 μg/mL
同位素/亚型 IgG1
UniProt登记号 P08833
储存温度 ?20℃
Gene Information human ... IGFBP1(3484)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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