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Anti-TTBK1 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3500002
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
5045.46 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-TTBK1 antibody produced in rabbit
Anti-BDTK
Anti-Tau tubulin kinase 1
Anti-Brain derived tau kinase
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Tau tubulin kinase 1 (TTBK1) is a serine/threonine and tyrosine kinase. It belongs to the casein kinase 1 superfamily and is neuron-specific. The encoded protein has a kinase domain, a unique polyglutamate domain and several PEST (proline–glutamate–serine–threonine) sequences. The gene encoding TTBK1 is localized on human chromosome 6p21.1.

免疫原

TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.

应用

Anti-TTBK1 antibody produced in rabbit has been used in western blotting.

生化/生理作用

Tau tubulin kinase 1 (TTBK1) is responsible for phosphorylation of TDP-43 (TAR DNA binding protein), a protein associated with amyotrophic lateral sclerosis and frontotemporal lobar dementia. High expression or abundance of TTBK1 might be associated with neurodegeneration in these diseases. It also phosphorylates tau protein and might be associated with Alzheimer′s disease progression.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer′s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.

联系

The action of this antibody can be blocked using blocking peptide SBP3500002.

外形

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 predicted mol wt 145-151 kDa
species reactivity mouse, human
technique(s) immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号 Q5TCY1
UniProt登记号 Q5TCY1
运输 dry ice
储存温度 ?20℃
Gene Information human ... TTBK1(84630)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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