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位置: 首页> 品牌> Sigma-Aldrich> Anti-PABP-2 Antibody

Anti-PABP-2 Antibody

品牌
Sigma-Aldrich
货号
ABE371
规格纯度
serum, from rabbit
价格
4681.07 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-PABP-2 Antibody
Polyadenylate-binding protein 2, PABP-2, Poly(A)-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, PABII, Polyadenylate-binding nuclear protein 1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

PABPN1, also known as Polyadenylate-binding protein 2, Poly(A)-binding protein II (PABP-2), Poly(A)-binding protein 2, PABII, Nuclear poly(A)-binding protein 1,or Polyadenylate-binding nuclear protein 1, and encoded by the gene PABPN1/PAB2/PABP2, is a RNA binding protein involved in the 3′-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tails. PABPN1 stimulates poly(A) polymerase (PAPOLA) tail elongation and controls the poly(A) tail length. PABPN1is also important in nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA and appears to also protect the poly(A) tail from degradation. PABPN1 is localized to the nucleus and cytoplasm. PABPN1 is found in cytoplasmic mRNP granules containing untranslated mRNAs and shuttles between the nucleus and the cytoplasm but is predominantly found in the nucleus.

免疫原

Recombinant protein corresponding to bovine PABP-2.

应用

This Anti-PABP-2 antibody is validated for use in western blotting, IP & ICC for the detection of PABP-2.
Research Category
Epigenetics & Nuclear Function
Immunoprecipitation Analysis: A representative lot immunoprecipitated PABP-2 in mouse limb tissue lysate.
Immunocytochemistry Analysis: A representative lot detected PABP-2 in mouse limb cells.

质量

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected PABP-2 in 10 ?g of A431 cell lysate.

目标描述

~ 50 kDa observed. The calculated molecular weight is 34 kDa, however PABP-2 has been shown as a ~50 kDa band in western blots (Nemeth A. K, et al. (1995). Nucleic Acids Res. 23(20):4034-41).

外形

Unpurified
Rabbit polyclonal in buffer containing serum with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 serum
antibody product type primary antibodies
克隆 polyclonal
species reactivity rat, mouse, human
technique(s) immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号 NP_776994
UniProt登记号 Q28165
运输 wet ice
Gene Information human ... PABPN1(8106)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1

Sigma-Aldrich

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