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位置: 首页> 品牌> Sigma-Aldrich> Anti-MDA5 antibody produced in rabbit

Anti-MDA5 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB3500356
规格纯度
affinity isolated antibody, buffered aqueous solution
价格
6680.41 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-MDA5 antibody produced in rabbit
Anti-Melanoma differentiation-associated protein 5
Anti-Interferon-induced with helicase C domain protein 1
Anti-IFIH1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Melanoma differentiation-associated protein 5 (MDA5), also known as interferon induced with helicase C domain 1 (IFIH1), is a cytosolic RNA sensor. It is encoded by the gene mapped to human chromosome 2q24.2. The encoded protein is a member of the retinoic acid-inducible gene I-like receptor family. MDA5 is characterized with both caspase recruitment domain and putative DExH group RNA helicase domains.

免疫原

MDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.

应用

Anti-MDA5 antibody produced in rabbit has been used in western blot analysis.

生化/生理作用

Melanoma differentiation-associated protein 5 (MDA5) plays a vital role in antiviral innate immune responses. In addition, the encoded protein also activates interferon regulatory factors 3 and 7 and nuclear factor-κB (NF-κB) via a mitochondrial viral signaling protein, inducing antiviral and proapoptotic responses, which is associated with various autoimmune diseases, such as type 1 diabetes (T1D), Graves′ disease (GD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA). Polymorphism in the gene is associated with the development of generalized vitiligo (GV).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

联系

The action of this antibody can be blocked using blocking peptide SBP3500356.

外形

Supplied in PBS with 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 predicted mol wt 113 kDa
species reactivity human, mouse
technique(s) immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI登记号 NP_071451
UniProt登记号 Q9BYX4
运输 dry ice
储存温度 ?20℃
Gene Information human ... IFIH1(64135)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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