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Anti-LIMP II Antibody

品牌
Sigma-Aldrich
货号
ABC822
规格纯度
from rabbit, purified by affinity chromatography
价格
5854.74 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-LIMP II Antibody
Lysosome membrane protein 2, 85 kDa lysosomal membrane sialoglycoprotein, LGP85, CD36 antigen-like 2, Lysosome membrane protein II, LIMP II, Scavenger receptor class B member 2, CD36
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Lysosome membrane protein 2, also known as 85 kDa lysosomal membrane sialoglycoprotein (LGP85) or Lysosome membrane protein II (LIMP II) or Scavenger receptor class B member 2, and encoded by the gene name SCARB2 or CD36L2 or LIMPII, is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP II in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP II was shown to act as a receptor to bind β-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP II-deficient mice showed missorted as well as secreted β-glucocerebrosidase, suggesting that LIMP II also functions as the mannose-6-phosphate-independent trafficking receptor.

免疫原

Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human LIMP II.

应用

Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LIMP II in human skeletal muscle tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected LIMP II in human skeletal muscle cells.
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer
Anti-LIMP II Antibody is an antibody against LIMP II for use in western blotting, IHC & immunofluorescence.

质量

Evaluated by Western Blotting in human skeletal muscle tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected GPAT-1 in human skeletal muscle tissue lysate with and without blocking peptide.

目标描述

~80 kDa observed. Despite its predicted molecular weight, LIMP II runs at approximately 80 – 85 kDa in Western Blotting.

外形

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
technique(s) immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt登记号 Q14108
运输 wet ice
Gene Information human ... SCARB2(950)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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