半岛bd体育手机客户端 说明
一般描述
IL17RC (Interleukin 17 receptor C) is a novel single-pass transmembrane protein belonging to the interleukin-17 cytokine family. It is expressed in T cells and B cells with an extracellular N terminal domain. It is widely distributed in prostate, cartilage, kidney, liver, heart, and muscle, whereas at a lower level in thymus and leukocytes. It is mapped on human chromosome 3p25.3-3p24.1. Its expression has also been found in various cancerous cells such as prostate cancer.
免疫原
Interleukin-17 receptor C Precursor recombinant protein epitope signature tag (PrEST)
应用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
生化/生理作用
IL17RC (Interleukin 17 receptor C) is involved in the cytokine signaling pathway as a decoy receptor. It is essentially required for the signaling of IL-17A, IL-17F, and IL-17A/F bothin vitroandin vivo.In nonhemopoietic tissues, it couples with IL-17RA and forms a complex, which drives the functions of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. Inherited deficiency of IL17RC causes an autosomal recessive disorder, chronic mucocutaneous candidiasis (CMC), with recurrent or persistent infections of the skin, nail, oral, and genital mucosae.
特点和优势
Prestige Antibodies?are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies?to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
联系
Corresponding Antigen APREST72212.
外形
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律信息
Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
人类蛋白质图谱编号 | HPA019885 Human Protein Atlas characterization data |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 100 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
半岛bd体育手机客户端 线 | Prestige Antibodies?Powered by Atlas Antibodies |
形式 | buffered aqueous glycerol solution |
species reactivity | human |
包装 | antibody small pack of 25 μL |
technique(s) | immunohistochemistry: 1:50- 1:200 |
免疫原序列 | WDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNH |
UniProt登记号 | Q8NAC3 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... IL17RC(84818) |
安全信息
储存分类代码 | 10;12 - Combustible liquids;Non Combustible Liquids |
WGK | WGK 1 |
Sigma-Aldrich