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位置: 首页> 品牌> Sigma-Aldrich> Anti-Phospho- Bad (Ser75) Antibody

Anti-Phospho- Bad (Ser75) Antibody

品牌
Sigma-Aldrich
货号
AB10423
包装型号
规格纯度
from rabbit
价格
6190.47 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-Phospho- Bad (Ser75) Antibody
BCL-X/BCL-2 binding protein, BCL2-antagonist of cell death protein, BCL2-associated agonist of cell death, BCL2-binding component 6, BCL2-binding protein, Bcl-2-binding component 6, Bcl-2-like 8 protein, Bcl-XL/Bcl-2-associated death promoter
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Bad is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin are found to be involved in the regulation of this protein. Bad is phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.

特异性

This antibody reacts with the 18 kDa phospho-Bad (Ser75) protein.
Other species have not been tested.

免疫原

This antibody is generated in rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS75 of human Bad.

应用

Research Sub Category
Apoptosis - Additional
Anti-Phospho-Bad (Ser75) Antibody detects level of Phospho-Bad (Ser75) & has been published & validated for use in WB.
Research Category
Apoptosis & Cancer

质量

Western Blot Analysis: 1:250 dilution of this antibody detected phospho-Bad (Ser75) in lysate from LPS-stimulated RAW264.7 cells.

目标描述

18 kDa

外形

Format: Purified
Protein G followed by IAP
Purified immunoglobulins in PBS with 0.09% NaN3.

储存及稳定性

Store at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C

分析说明

Control
Western Blot : RAW264.7/LPS lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 polyclonal
species reactivity rat, mouse
species reactivity (predicted by homology) human (based on 100% sequence homology)
technique(s) western blot: suitable
NCBI登记号 NP_116784
UniProt登记号 Q92934
运输 wet ice

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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