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位置: 首页> 品牌> Sigma-Aldrich> Anti-BMP-9 (GDF-2)

Anti-BMP-9 (GDF-2)

品牌
Sigma-Aldrich
货号
ABN1024
规格纯度
from rabbit, purified by affinity chromatography
价格
5016.79 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-BMP-9 (GDF-2)
Bone morphogenetic protein 9, Growth/differentiation factor 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Growth/differentiation factor 2 (UniPort: Q9UK05; also known as GDF-2, Bone morphogenetic protein 9, BMP-9) is encoded by the GDF2 (also known as BMP9) gene (Gene ID: 2658) in human. BMP-9 is a member of the TGF-beta family that forms a signaling complex with two type 1 and two type II receptors. It is synthesized with a signal peptide of (aa 1-22) and a propeptide (aa 22-319). The signal peptide is cleaved in the mature protein. The propeptide of BMP-9 does not interfere with the biological activity of BMP-9 and is believed to remain associated with the mature peptide. BMP9 is constitutively secreted from the liver in an active form into the circulation. BMP-9 signals through high affinity activing receptor-like kinase 1 (ALK1) in endothelial cells and maintains endothelial homeostasis. It is also considered as a potent osteogenic signaling factor in mesenchymal stem cells. BMP-9 is also known to induce an increase in collagen, fibronectin, and connective tissue growth factor expression associated with Smad 1/5/8, Smad 2/3, and Erk1/2 activation. It is also reported to promote the acquisition of the cholinergic phenotype in basal forebrain cholinergic neurons during development and protects these neurons. Defects in BMP9 gene are known to cause Telangiectasia, hereditary hemorrhagic disease that leads to vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera and causes recurrent epistaxis and gastro-intestinal hemorrhage (Ref.: Wei, Z et al. (2014). J. Biol. Chem. 289 (45); 31150 31159; Munoz-Felix, JM et al. (2016). Cell Signal 28(9): 1252-1261).

特异性

This rabbit polyclonal antibody detects human Bone morphogenetic protein 9 (BMP-9). It targets an epitope within 110 amino acids from the C-terminal region.

免疫原

GST-tagged recombinant fragment corresponding to 110 amino acids from the C-terminal region of human Bone morphogenetic protein 9 (BMP-9).

Epitope: C-terminus

应用

Research Category
Neuroscience
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BMP-9 (GDF-2) in human liver and human liver cancer tissues.

Anti-BMP-9 (GDF-2), Cat. No. ABN1024, is a highly specific rabbit polyclonal antibody that targets Bone morphogenetic protein 9 (Growth/differentiation factor 2) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

质量

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.25 ?g/mL of this antibody detected BMP-9 (GDF-2) in 10 ?g of human liver tissue lysate.

目标描述

~45 kDa observed; 47.32 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine, 0.15 M NaCl, pH7.4 with 0.05% sodium azide.

Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
纯化方式 affinity chromatography
species reactivity human
包装 antibody small pack of 25 μL
technique(s) immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型 IgG
NCBI登记号 NP_057288.1
UniProt登记号 Q9UK05
运输 ambient

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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