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位置: 首页> 品牌> Sigma-Aldrich> Deracoxib

Deracoxib

品牌
Sigma-Aldrich
CAS
169590-41-4
货号
SML2014
规格纯度
≥98% (HPLC)
价格
1387.85 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
169590-41-4
Deracoxib
4-[3-(Difluoromethyl)-5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl]benzenesulfonamide
SC-046
SC-46
SC-59046
4-[5-(3-Fluoro-4-methoxyphenyl)-3-(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Deracoxib is an orally active cyclooxygenase-2 (COX-2) inhibitor with >48-fold selectivity over COX-1 (IC50 of 203-189 nM against COX-2-dependent PGE2 production vs. IC50 of 9.85-9.96 μM against COX-1-dependent TxB2 production in dog whole blood). Deracoxib is also reported to exhibit inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3) as well as positive modulatory effiacy toward 2-APB-stimulated transient receptor potential vanilloid 3 channel (TRPV3) activity.

基本信息

经验(实验)分子式 C17H14F3N3O3S
分子量 397.37
NACRES NA.77

半岛bd体育手机客户端 性质

测定 ≥98% (HPLC)
形式 powder
颜色 white to brown
溶解性 DMSO: 2 mg/mL, clear
储存温度 room temp
InChI 1S/C17H14F3N3O3S/c1-26-16-7-2-10(8-13(16)18)15-9-14(17(19)20)22-23(15)11-3-5-12(6-4-11)27(21,24)25/h2-9,17H,1H3,(H2,21,24,25)
InChI key WAZQAZKAZLXFMK-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P301 + P312 + P330
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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