α-(Methylamino)isobutyric acid

半岛bd体育手机客户端 说明

应用

α-(Methylamino)isobutyric acid (MeAIB) has been used:

• as a system A transport system inhibitor to perform inhibition experiments
• as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
• as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of¹⁴C-cysteine/ radioactive-labeled cysteine

包装

250 mg in poly bottle
1 g in poly bottle

生化/生理作用

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

基本信息

线性分子式	CH3NHC(CH3)2COOH
分子量	117.15
Beilstein	1746984
EC 号	219-898-2
MDL编号	MFCD00004191
PubChem化学物质编号	24896726
NACRES	NA.26

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (titration)
形式	powder
technique(s)	ligand binding assay: suitable
颜色	white
mp	>300 ℃ (lit.)
储存温度	?20℃
SMILES string	CNC(C)(C)C(O)=O
InChI	1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)
InChI key	DLAMVQGYEVKIRE-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves