半岛bd体育手机客户端 说明

应用

Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.

包装

1 g in glass bottle
100 mg in glass bottle

生化/生理作用

Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

经验(实验)分子式	C6H10N6O
分子量	182.18
EC 号	224-396-1
MDL编号	MFCD00057167
PubChem化学物质编号	24893683
NACRES	NA.85

半岛bd体育手机客户端 性质

质量水平	100
形式	powder or crystals
溶解性	1 M HCl: 50 mg/mL
作用机制	DNA synthesis | interferes
抗生素抗菌谱	neoplastics
储存温度	2-8℃
SMILES string	CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI	1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key	FDKXTQMXEQVLRF-ZHACJKMWSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
预防措施声明	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges