半岛bd体育手机客户端 说明
一般描述
A cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed thatin vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor forclasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50approximately 1 ?M).clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystinin vitro.
A highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed thatin vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor forclasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome.
包装
100 μg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
20S proteasome
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
其他说明
Corey, E.J., and Wei-Dong, Z. 1999.Chem. Pharm. Bull.47,1.
Dick, L.R., et al. 1997.J. Biol. Chem.272,182.
Dick, L.R., et al. 1996.J. Biol. Chem.271,7273.
Fenteany, G., et al. 1995.Science268,726.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C10H15NO4 |
| 分子量 | 213.23 |
| MDL编号 | MFCD01076526 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMSO: 3 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
Sigma-Aldrich
m.cnreagent.com
