半岛bd体育手机客户端 说明
一般描述
A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH; IC50= 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH). Reported to decrease human VSMC (vascular smooth muscle cell) proliferation.
A cell-permeable, potent, selective, competitive, and tight binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH) (IC50= 9.8 nM for recombinant murine sEH and 85.2 nM for recombinant human sEH). Also displays anti-hypertensive and anti-inflammatory properties. Reported to decrease human vascular smmoth muscle cell (VSMC) proliferation.
包装
25 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
Soluble epoxide hydrolase
Reversible: no
Product competes with ATP.
Target IC50: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Newman, J.W., et al. 2003.Proc. Natl. Acad. Sci. USA100,1558.
Davis, B.B., et al. 2002.Proc. Natl. Acad. Sci. USA99,2222.
Morisseau, C., et al. 2002.Biochem. Pharmacol.63,1599.
Imig, J.D., et al. 2002.Hypertension39,690.
Argiriadi, M.A., et al. 2000.J. Biol. Chem.275,15265.
Yu, Z., et al. 2000.Circ. Res.87,992.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H38N2O |
| 分子量 | 310.52 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | dichloromethane: 1 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
