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位置: 首页> 品牌> Sigma-Aldrich> (±)-β-(氨甲基)-4-氯苯丙酸

(±)-Baclofen

(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid

品牌
Sigma-Aldrich
CAS
1134-47-0
货号
B5399
规格纯度
≥98% (TLC), solid
价格
781.56 *本价格含增值税费
促销
服务
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半岛bd体育手机客户端 名称:
1134-47-0
(±)-Baclofen
(±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid
Lioresal
(±)-巴氯芬
(±)-β-(氨甲基)-4-氯苯丙酸
巴氯芬片
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABABreceptor agonist:

  • as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
  • to test its effects on in vivo motor function tests and performance of mutant mice
  • to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
  • to test its effect in reducing dendritic excitability in Purkinje neurons

生化/生理作用

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABAB受体激动剂;骨骼肌松弛剂;解痉剂。

基本信息

经验(实验)分子式 C10H12ClNO2
分子量 213.66
EC 号 214-486-9
MDL编号 MFCD00055143
PubChem化学物质编号 24278146
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (TLC)
形式 solid
颜色 white to very faintly yellow
溶解性 1 M HCl: 50 mg/mL
储存温度 2-8℃
SMILES string ClC1=CC=C(C(CN)CC(O)=O)C=C1
InChI 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChI key KPYSYYIEGFHWSV-UHFFFAOYSA-N
Gene Information human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H301
预防措施声明 P264 - P270 - P301 + P310 - P405 - P501
危险分类 Acute Tox. 3 Oral
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Sigma-Aldrich

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