半岛bd体育手机客户端 说明

一般描述

Eicosapentaenoic acid (EPA)/timnodonic acid is an omega-3 polyunsaturated fatty acid (PUFA). This long-chain fatty acid is mainly found in fish oil.

应用

cis-5,8,11,14,17-Eicosapentaenoic acid sodium salt has been used:

• to study its effect on the pathology of lupus in drug-induced and spontaneous mouse models
• to pretreat mouse alveolar macrophages to study the effect/relationship between amiodarone and eicosapentaenoic acid (EPA) concerning the cytokine release
• to examine if pharmacological correction with EPA supplementation might restore autophagic flux and reduce renal lipotoxicity in mice

生化/生理作用

Eicosapentaenoic acid (EPA) possesses anti-hyperglycemic, anti-oxidant, anti-hyperlipidemic, and anti-inflammatory properties. It aids in improving vasoreactivity. EPA is capable of suppressing vascular smooth muscle proliferation. It ameliorates pulmonary hypertension by preventing Fyn kinase activity. EPA exhibits a beneficial effect on lipid metabolism. It is used to treat hypercholesterolemia and atherosclerosis.
5-脂氧合酶抑制剂；可减少血栓素 A2 的生成。

基本信息

线性分子式	CH3(CH2CH=CH)5(CH2)3CO2Na
分子量	324.43
MDL编号	MFCD00079184
PubChem化学物质编号	24894631
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
生物来源	synthetic (organic)
测定	≥99% (capillary GC)
形式	film or powder
颜色	white to off-white
溶解性	methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
运输	dry ice
储存温度	?20℃
SMILES string	[Na].CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
InChI	1S/C20H30O2.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;;/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22);;/b4-3-,7-6-,10-9-,13-12-,16-15-;;
InChI key	TVEGTERCKGGVCJ-LIJGWLRISA-N
Gene Information	human ... ALOX5(240) mouse ... ALOX5(11689) rat ... ALOX5(25290)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)