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位置: 首页> 品牌> Sigma-Aldrich> 1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

TBPB

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

品牌
Sigma-Aldrich
CAS
634616-95-8
货号
SML0453
包装型号
规格纯度
≥98% (HPLC)
价格
1179.67 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
634616-95-8
TBPB
1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

特点和优势

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C25H32N4O
分子量 404.55
MDL编号 MFCD22666590
PubChem化学物质编号 329824732
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 5 mg/mL (clear solution; warmed)
储存温度 2-8℃
SMILES string Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45
InChI 1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
InChI key CWPKTBMRVATCBL-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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