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Dp44mT

品牌
Sigma-Aldrich
CAS
152095-12-0
货号
SML0186
规格纯度
≥98% (HPLC)
价格
991.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
152095-12-0
Dp44mT
2-(Di-2-pyridinylmethylene)-N,N-dimethyl-hydrazinecarbothioamide
Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Dp44mT may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Dp44mT (di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone) influences lysosome integrity through copper binding. It induces reactive oxygen species (ROS) generation by redox cycling of iron complex. Dp44mT exhibits anti cancer action by attenuating Ndrg-1 (N-myc downstream regulated 1), a metastasis suppressor protein. It also alters the cyclin family of proteins (A, B, D1, D2,D3 and cyclin-dependent kinase 2) known for cell-cycle regulation. Dp44mT is known to promote apoptosis in neuroepithelioma, melanoma and breast cancer.
Dp44mT is an iron chelator that works as a selective anticancer agent. As other iron chelators it can serve as a therapeutic adjunct to doxorubicin treatment. Additionally Dm44mT possess DNA-damaging activity. It appears that that activity is mediated by top2a inhibition.

特点和优势

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

注意

Material appears to be unstable in solution; make solutions immediately before use.

基本信息

经验(实验)分子式 C14H15N5S
分子量 285.37
MDL编号 MFCD20527329
PubChem化学物质编号 329825215
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 yellow to orange
溶解性 DMSO: ≥5 mg/mL
创始人 Bayer
储存温度 2-8℃
SMILES string CN(C)C(=S)N\N=C(\c1ccccn1)c2ccccn2
InChI 1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H,1-2H3,(H,18,20)
InChI key XOBIGRNRXCAMJQ-UHFFFAOYSA-N

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H301
预防措施声明 P301 + P310
危险分类 Acute Tox. 3 Oral
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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