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AS605240

品牌
Sigma-Aldrich
CAS
648450-29-7
货号
A0233
规格纯度
≥98% (HPLC)
价格
1538.21 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
648450-29-7
AS605240
5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

AS605240 has been used:

  • as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.
  • as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.
  • as a class 1A PI3K inhibitor to treat CD4+T cells.

包装

5, 25 mg in glass bottle

生化/生理作用

AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.
AS605240 is a potent and selective PI3Kγ inhibitor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C12H7N3O2S
分子量 257.27
MDL编号 MFCD11100415
PubChem化学物质编号 329770591
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 , faint red to orange to dark brown
溶解性 DMSO: 1 mg/mL, clear (warmed)
储存温度 2-8℃
SMILES string O=C1NC(=O)C(\S1)=C\c2ccc3nccnc3c2
InChI 1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-
InChI key SQWZFLMPDUSYGV-POHAHGRESA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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