6,8-Bis(benzylthio)-octanoic acid

半岛bd体育手机客户端 说明

应用

6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:

• to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cells
• to induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysates
• to validate basal respiration in tissue respirometry

包装

5, 25 mg in glass bottle

生化/生理作用

6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer.

其他说明

Air Sensitive

基本信息

经验(实验)分子式	C22H28O2S2
分子量	388.59
MDL编号	MFCD22420826
PubChem化学物质编号	329825400
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL (clear solution)
储存温度	2-8℃
SMILES string	OC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2
InChI	1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)
InChI key	ZYRLHJIMTROTBO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H410
预防措施声明	P273 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable