半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
基本信息
| 经验(实验)分子式 | C18H12N4O3 |
| 分子量 | 332.31 |
| MDL编号 | MFCD00576774 |
| PubChem化学物质编号 | 329799918 |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | red |
| 溶解性 | DMSO: >10 mg/mL |
| 储存温度 | room temp |
| SMILES string | [O-][N+](=O)c1ccc(Nc2ccccc2-c3ccccc3)c4nonc14 |
| InChI | 1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H |
| InChI key | KMJPYSQOCBYMCF-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
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