SD-208

半岛bd体育手机客户端 说明

应用

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

包装

5, 25 mg in glass bottle

生化/生理作用

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹
SD-208 is TGF-βR I kinase inhibitor with IC₅₀=49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

基本信息

经验(实验)分子式	C17H10ClFN6
分子量	352.75
MDL编号	MFCD11519969
PubChem化学物质编号	24899731
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white to tan
溶解性	DMSO: >5 mg/mL
储存温度	2-8℃
SMILES string	Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
InChI	1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChI key	BERLXWPRSBJFHO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves