半岛bd体育手机客户端 说明

应用

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

包装

5, 25 mg in glass bottle

生化/生理作用

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.

注意

hygroscopic

基本信息

经验(实验)分子式	C27H38N2O4· HCl · xH2O
分子量	491.06 (anhydrous basis)
EC 号	205-800-5
MDL编号	MFCD11046028
PubChem化学物质编号	24900706
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]22/D +9.6°, c = 0.5 in ethanol(lit.)
储存条件	desiccated
颜色	white
溶解性	H2O: >30 mg/mL ethanol: soluble
SMILES string	O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI	1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
InChI key	ICKXRKHJKXMFLR-KFSCGDPASA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 + H311 + H331
预防措施声明	P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
危险分类	Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges