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位置: 首页> 品牌> Sigma-Aldrich> PS-1145 二盐酸盐

PS-1145 dihydrochloride

PS-1145 二盐酸盐

品牌
Sigma-Aldrich
CAS
431898-65-6
货号
P6624
规格纯度
≥98% (HPLC), solid
价格
2023.95 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
431898-65-6
PS-1145 dihydrochloride
N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
PS-1145 二盐酸盐
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

PS-1145 dihydrochloride has been used as an IκB kinase (IKK) inhibitor:

  • in the culture medium to treat human epidermal keratinocytes (HEKs) and squamous carcinoma cells (SCCs) to study the role of IKK inCorynebacterium tuberculostearicum(C. t.)-elicited transcription of inflammatory mediators
  • to investigate the involvement of transcription factor p65 (RelA)/nuclear factor kappa-B (NF-κB) in the cluster of differentiation 28 (CD28)-mediated interleukin-17A (IL-17A) gene expression
  • to examine the involvement of NF-κB signaling in the cytotoxic effect of niclosamide on colorectal cancer (CRC) cells

包装

5, 25 mg in glass bottle

生化/生理作用

PS-1145, a β-carboline derivative, blocks the phosphorylation and degradation of the inhibitor of nuclear factor kappa-β (NF-κB;). It also inhibits the subsequent activation of nuclear factor kappa-β (NF-κB) and thereby prevents the release of tumor necrosis factor-α (TNF-α) in lipopolysaccharide treated mice. PS-1145 hinders pro-inflammatory cytokine production and cell proliferation. It plays a potential therapeutic role in carcinogenesis in multiple myeloma. PS-1145 exhibits anti-tumor activity on nasopharyngeal carcinoma (NPC) cell lines.
PS-1145 is an I K B kinase (IKK) inhibitor.

特点和优势

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C17H11ClN4O · 2HCl
分子量 395.67
MDL编号 MFCD08705411
PubChem化学物质编号 24724584
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 yellow
溶解性 DMSO: >3 mg/mL at ~60 ℃, clear (with warming for 2 minutes)
methanol: water (1:1): ≥5 mg/mL at 60 ℃ (With warming for 5 minutes.)
储存温度 2-8℃
SMILES string Cl[H].Cl[H].Clc1cc(NC(=O)c2cccnc2)c3[nH]c4cnccc4c3c1
InChI 1S/C17H11ClN4O.2ClH/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10;;/h1-9,21H,(H,22,23);2*1H
InChI key QTDCBADLGJZBHP-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
危险分类 Acute Tox. 4 Oral
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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