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NPS2143 hydrochloride

品牌
Sigma-Aldrich
CAS
324523-20-8
货号
SML0362
规格纯度
≥98% (HPLC)
价格
1843.44 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
324523-20-8
NPS2143 hydrochloride
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
NPS-2143 hydrochloride
SB-262470-A hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :

  • In the regulation of intestinal calcium transport.
  • In the regulation of local negative feedback of intestinal calcium absorption.
  • In sensorimotor decision making during development.

包装

5, 25 mg in glass bottle

生化/生理作用

NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.

基本信息

经验(实验)分子式 C24H25ClN2O2· HCl
分子量 445.38
MDL编号 MFCD16038896
PubChem化学物质编号 329825364
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
旋光性 [α]20/D +20 to +24°, c = 1.0 in methanol
颜色 white to beige
溶解性 DMSO: >10 mg/mL
储存温度 2-8℃
SMILES string Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N
InChI 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1
InChI key ZEBNDUQLNGYBNL-VEIFNGETSA-N

安全信息

象形图 GHS07GHS09
警示用语: Warning
危险声明 H302 + H312 + H332 - H410
预防措施声明 P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
危险分类 Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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