半岛bd体育手机客户端 说明
应用
Metabolomics research
Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
基本信息
| 经验(实验)分子式 | C18H18ClN3O · 2HCl |
| 分子量 | 400.73 |
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 生物来源 | synthetic |
| 测定 | ≥95% |
| 形式 | solid |
| technique(s) | HPLC: suitable |
| 颜色 | yellow to dark yellow |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
