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位置: 首页> 品牌> Sigma-Aldrich> HIF-2 Antagonist 2

HIF-2 Antagonist 2

品牌
Sigma-Aldrich
CAS
1422955-31-4
货号
SML0883
规格纯度
≥98% (HPLC)
价格
1168.11 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
1422955-31-4
HIF-2 Antagonist 2
N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

Hypoxia inducible transcription factors (HIF) control gene expression when oxygen availability is low and are associated with the onset and progression of a variety of cancers. They are heterodimers of an HIF-α (HIF-1α, HIF-2α also known as EPAS-1, or HIF-3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β). N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine is a highly selective antagonist of HIF-2 heterodimerization, DNA-binding activity, and target gene transcription. It binds the HIF-2α PAS-B domain with a KD ~80 nM compared to a KD > 5000 nM for the HIF-1α PAS-B domain.

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式 C12H6ClFN4O3
分子量 308.65
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 15 mg/mL, clear
储存温度 room temp

安全信息

储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 3

Sigma-Aldrich

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