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CI 976

品牌
Sigma-Aldrich
CAS
114289-47-3
货号
C3743
规格纯度
>98% (HPLC), solid
价格
2264.41 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
114289-47-3
CI 976
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

  • to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
  • to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
  • to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

包装

5 mg in glass bottle

生化/生理作用

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT)in vitro.CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

基本信息

经验(实验)分子式 C23H39NO4
分子量 393.56
MDL编号 MFCD00869662
PubChem化学物质编号 329775044
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 >98% (HPLC)
形式 solid
溶解性 DMSO: >10 mg/mL
H2O: insoluble <2 mg/mL
储存温度 2-8℃
SMILES string CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
InChI 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
InChI key WAFNZAURAWBNDZ-UHFFFAOYSA-N

安全信息

危险声明 H413
危险分类 Aquatic Chronic 4
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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