半岛bd体育手机客户端 说明
应用
CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:
包装
5 mg in glass bottle
生化/生理作用
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT)in vitro.CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.
基本信息
经验(实验)分子式 | C23H39NO4 |
分子量 | 393.56 |
MDL编号 | MFCD00869662 |
PubChem化学物质编号 | 329775044 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | >98% (HPLC) |
形式 | solid |
溶解性 | DMSO: >10 mg/mL H2O: insoluble <2 mg/mL |
储存温度 | 2-8℃ |
SMILES string | CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC |
InChI | 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25) |
InChI key | WAFNZAURAWBNDZ-UHFFFAOYSA-N |
安全信息
危险声明 | H413 |
危险分类 | Aquatic Chronic 4 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich