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BAY 73-6691

品牌
Sigma-Aldrich
CAS
794568-92-6
货号
B3561
规格纯度
≥98% (HPLC), powder
价格
2197.44 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
794568-92-6
BAY 73-6691
1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one
半岛bd体育手机客户端 介绍:

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应用

BAY 73-6691 has been used as a phosphodiesterase 9 inhibitor in ischemic heart samples and in structural studies. It may be used as a PDE 9 inhibitor in neuroblastoma SH-SY5Y cells.

包装

5, 25 mg in glass bottle

生化/生理作用

BAY 73-6691 was characterized in vitroas the first potent and selective inhibitor of phosphodiesterase 9 (PDE9), which is currently under preclinical development for the treatment of Alzheimer′s disease. This compound selectively inhibits human (IC50= 55 nM) and murine (IC50= 100 nM) PDE9 activityin vitroand shows only moderate activity against other cyclic nucleotide-specific phosphodiesterases. BAY 73-6691 alone did not significantly increase basal cGMP levels. The PDE9 inhibitor significantly potentiated the cGMP signals generated by sGC activating compounds such as BAY 58-2667 or 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine (BAY 41-2272) and induced leftward shifts of the corresponding concentration-response curves. The newly generated PDE9 reporter cell line show that BAY 73-6691 is able to efficiently penetrate cells and to inhibit intracellular PDE9 activity.?

特点和优势

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式 C15H12ClF3N4O
分子量 356.73
MDL编号 MFCD08705319
PubChem化学物质编号 24724419

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 off-white
溶解性 DMSO: >20 mg/mL
创始人 Bayer
储存温度 2-8℃
SMILES string C[C@H](CC1=Nc2c(cnn2-c3ccccc3Cl)C(=O)N1)C(F)(F)F
InChI 1S/C15H12ClF3N4O/c1-8(15(17,18)19)6-12-21-13-9(14(24)22-12)7-20-23(13)11-5-3-2-4-10(11)16/h2-5,7-8H,6H2,1H3,(H,21,22,24)/t8-/m1/s1
InChI key FFPXPXOAFQCNBS-MRVPVSSYSA-N

安全信息

象形图 GHS06
警示用语: Danger
危险声明 H300 - H315 - H319 - H335 - H413
预防措施声明 P273 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
危险分类 Acute Tox. 2 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Sigma-Aldrich

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