AK-7

半岛bd体育手机客户端 说明

一般描述

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

应用

AK-7 has been used in cell culture and cell treatment.

包装

5, 25 mg in glass bottle

生化/生理作用

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotectivein vitroand decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

基本信息

经验(实验)分子式	C19H21BrN2O3S
分子量	437.35
MDL编号	MFCD03140195
PubChem化学物质编号	329825200
NACRES	NA.25

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to tan
溶解性	DMSO: ≥15 mg/mL
储存温度	2-8℃
SMILES string	Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
InChI	1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
InChI key	IYAYHZZWYNXHEQ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable