Phenylmethylsulfonyl Fluoride-CAS 329-98-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 ?M.

包装

1 g in Alu drum
5 g in Glass bottle
25 g in Fibre case

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
serine proteases
Cell permeable: no

警告

Toxicity: Corrosive (L)

重悬

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
t_?= 1 hour at pH 7.5. Effective concentration: 50 μM.

其他说明

Seitz, R., et al. 1993.Int. J. Cancer53,514.
Weaver, V.M., et al. 1993.Biochem. Cell. Biol.71,488.
Bourgain, R.H., et al. 1992.Adv. Exp. Med. Biol.316,427.
Chang, C.T., et al. 1992.Biochem. Int.28,707.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C7H7FO2S
分子量	174.19
MDL编号	MFCD00007424
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	200
测定	≥99% (GC)
形式	crystalline solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated
颜色	white to off-white
溶解性	ethanol: soluble isopropanol: soluble methanol: soluble
运输	ambient
储存温度	10-30℃
InChI	1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key	YBYRMVIVWMBXKQ-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H314
预防措施声明	P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类	Acute Tox. 3 Oral - Skin Corr. 1B
储存分类代码	6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable