半岛bd体育手机客户端 说明
一般描述
A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50= 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50= 200 ?M). Does not act as an antioxidant at higher concentrations (1 ?M to 10 mM). Exhibits neuroprotection inin vivoandin vitromodels of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).
A water-soluble phenanthridinone-derivative that acts as a potent anti-inflammatory agent and an inhibitor of poly(ADP-ribose) polymerase (PARP; EC50= 20 nM). Shown to be about 10,000-fold more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350) (EC50= 200 ?M). Suppresses neutrophil infiltration and nitric oxide production in peritonitis. Does not act as an antioxidant even at higher concentrations (1 ?M to 10 ?M). PJ34 inhibits peroxynitrite-induced cell necrosis with an (EC50= 20 nM). Exhibits neuroprotective effects inin vivoandin vitromodels of stroke.
包装
1, 5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
EC50 = 20 nM inhibiting poly(ADP-ribose) polymerase (PARP)
Product does not compete with ATP.
Reversible: no
Primary Target
PARP
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Abdelkarim, G.E., et al. 2001.Int. J. Mol. Med.7,255.
Garcia-Soriano, F.G., et al. 2001.Nature Med.7,108.
Mabley, G.J., et al. 2001.Inflamm. Res.50,561.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C17H17N3O2· xHCl |
| 分子量 | 295.34 (free base basis) |
| NACRES | NA.77 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | water: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
