TX-1123-CAS 157397-06-3-Calbiochem

品牌

Sigma-Aldrich

CAS

157397-06-3

货号

655200

包装型号

10 MG, A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC at much higher concentrations.

规格纯度

A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC at much higher concentrations.

价格

2340.22 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

157397-06-3
TX-1123-CAS 157397-06-3-Calbiochem
2-((3,5-di- tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione, PKA Inhibitor XII

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, reversible and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as a kinase inhibitor for Src, eEF2-K, and PKA (IC₅₀= 2.2, 3.2, and 9.6 ?M, respectively). Inhibits EGFR-K and PKC only at much higher concentrations (IC₅₀= 320 ?M). Reported to exhibit potent anti-tumor activity (EC₅₀= 3.66 and 39 ?M in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 (Cat. No. 658425). May be useful as a therapeutic agent for cancer treatment in animal models.
A cell-permeable, reversible, and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as an inhibitor for Src, eEF2-K, and PKA (IC₅₀= 2.2, 3.2, and 9.6 ?M, respectively), while it inhibits EGFR-K and PKC at much higher concentrations (IC₅₀= 320 ?M). Displays potent antitumor activity (EC₅₀= 3.66 and 39 ?M in HepG2 and HCT116 tumor cells, respectively) with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 (Cat. No. 658425). It is therefore a more promising candidate as a therapeutic agent for cancer treatment.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 2.2, 3.2, and 9.6 ?M against Src, eEF2-K, and PKA, respectively
Primary Target
Src
Product competes with ATP.
Reversible: yes

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (- 20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hori, H., et al. 2003.Cell. Mol. Biol. Lett.8,528.
Hori, H., et al. 2002.Bioorg. Med. Chem.10,3257.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₂₄O₃
分子量	312.40

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable