JAK2 Inhibitor II-CAS 1837-91-8-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 ?M in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 ?M in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.

包装

25 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
JAK2 autophosphorylation
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Sandberg, E.M., et al. 2005.J. Med. Chem.48,2526.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C6H6Br6
分子量	557.54
MDL编号	MFCD00059127

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (GC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	off-white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI key	QFQZKISCBJKVHI-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319
预防措施声明	P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable