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位置: 首页> 品牌> Sigma-Aldrich> SHP1/2 PTPase Inhibitor, NSC-87877-CAS 56932-43-5-Calbiochem

SHP1/2 PTPase Inhibitor, NSC-87877-CAS 56932-43-5-Calbiochem

品牌
Sigma-Aldrich
CAS
56932-43-5
货号
565851
规格纯度
The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
价格
1954.93 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
56932-43-5
SHP1/2 PTPase Inhibitor, NSC-87877-CAS 56932-43-5-Calbiochem
8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50= 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50= 1.69 ?M and 7.75 ?M, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

包装

50 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
Product does not compete with ATP.
Reversible: no
Primary Target
SHP1/2 PTPase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Chen, L., et al. 2006.Mol. Pharmacol.70,562.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C19H11N3Na2O7S2
分子量 503.42

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
desiccated (hygroscopic)
protect from light
颜色 red-brown
溶解性 water: 10 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
InChI key YOGRUDWAJPVHEL-LLDDCTHSSA-L

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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