Elastase Inhibitor IV-CAS 127373-66-4-Calbiochem

品牌

Sigma-Aldrich

CAS

127373-66-4

货号

324759

包装型号

1 MG, The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

规格纯度

The Elastase Inhibitor IV, also referenced under CAS 127373-66-4, controls the biological activity of Elastase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

价格

1560.15 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

127373-66-4
Elastase Inhibitor IV-CAS 127373-66-4-Calbiochem
N-( o-( p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
N-( o-( p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine, N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable, potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀= 19-49 nM using rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays about 100-fold greater selectivity over pancreatic elastase (IC₅₀= 5.6 ?M) and is inactive against trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 ?M. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeabilityin vivo. Also reported to inhibit mast cell Stat6-protease.
A cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀= 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Displays >100-fold greater selectivity over pancreas elastase (IC₅₀= 5.6 ?M). Does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 ?M. Effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeabilityin vivo. Also reported to inhibit mast cell Stat6-protease.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Neutrophil elastase
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Suzuki, K., et al. 2003.Biochem. Biophys. Res. Commun.309,768.
Kawabata, K., et al. 1991.Biochem. Biophys. Res. Commun.177,814.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₂₂N₂O₇S
分子量	434.46

半岛bd体育手机客户端性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze protect from light
颜色	white to off-white
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key	BTGNGJJLZOIYID-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable