半岛bd体育手机客户端 说明
一般描述
Zibotentan is an orally bioavailable, non-peptide ETA(endothelin) receptor-specific antagonist, with no activity against ETBreceptor.
包装
5, 25 mg in glass bottle
生化/生理作用
Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.
Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.
基本信息
经验(实验)分子式 | C19H16N6O4S |
分子量 | 424.43 |
MDL编号 | MFCD09955343 |
PubChem化学物质编号 | 329825958 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | white to beige |
溶解性 | DMSO: 5 mg/mL, clear (warmed) |
储存温度 | ?20℃ |
SMILES string | O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O |
InChI | 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25) |
InChI key | FJHHZXWJVIEFGJ-UHFFFAOYSA-N |
Gene Information | human ... EDNRA(1909) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
预防措施声明 | P301 + P312 + P330 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich