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位置: 首页> 品牌> Sigma-Aldrich> Zibotentan

Zibotentan

品牌
Sigma-Aldrich
CAS
186497-07-4
货号
SML1550
规格纯度
≥98% (HPLC)
价格
1117.23 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
186497-07-4
Zibotentan
N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulfonamide
ZD4054
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Zibotentan is an orally bioavailable, non-peptide ETA(endothelin) receptor-specific antagonist, with no activity against ETBreceptor.

包装

5, 25 mg in glass bottle

生化/生理作用

Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.
Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.

基本信息

经验(实验)分子式 C19H16N6O4S
分子量 424.43
MDL编号 MFCD09955343
PubChem化学物质编号 329825958

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 5 mg/mL, clear (warmed)
储存温度 ?20℃
SMILES string O=S(C1=C(C2=CC=C(C3=NN=CO3)C=C2)N=CC=C1)(NC4=NC=C(C)N=C4OC)=O
InChI 1S/C19H16N6O4S/c1-12-10-21-17(19(23-12)28-2)25-30(26,27)15-4-3-9-20-16(15)13-5-7-14(8-6-13)18-24-22-11-29-18/h3-11H,1-2H3,(H,21,25)
InChI key FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Gene Information human ... EDNRA(1909)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
预防措施声明 P301 + P312 + P330
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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