N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N′-methyl-urea

WYE-125132

品牌

Sigma-Aldrich

CAS

1144068-46-1

货号

PZ0321

包装型号

规格纯度

≥97% (HPLC)

价格

1117.23 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

1144068-46-1
WYE-125132
WYE-132
N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N′-methyl-urea

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

包装

5, 25 mg in glass bottle

生化/生理作用

WYE-125132 (WYE-132) is a highly potent, ATP-competitive, and specific inhibitor of mTOR with an IC₅₀value of 0.19 nM. Unlike rapamycin, which ihibits mTOR through allosteric binding to mTOR complex 1 (mTORC1) only, WYE-132 inhibits both mTORC1 and mTORC2. WYE-125132 is >5000-fold selective for mTOR vs. phosphoinositide 3-kinase (PI3K). WYE-132 induced apoptosis in a variety of cancer lines including LNCap prostate cells and H1975 lung cancer cells. WYE-132 also inhibited ovarian cancer cell growth.

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₇H₃₃N₇O₄
分子量	519.60

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^?
颜色	white to beige
溶解性	DMSO: 20 mg/mL, clear
创始人	Pfizer
储存温度	?20℃

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3